Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men
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چکیده
منابع مشابه
Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients.
Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormad1 is essential for mammalian gametogenesis as knockout male mice are infertile. Hormad1-deficient testes exhibit meiotic arre...
متن کاملnew single nucleotide polymorphism g5508a in the sept12 gene may be associated with idiopathic male infertility in iranian men
background: male infertility is a multifactorial disorder, which affects approximately 10% of couples at childbearing age with substantial clinical and social impact. genetic factors are associated with the susceptibility to spermatogenic impairment in humans. recently, sept12 is reported as a critical gene for spermatogenesis. this gene encodes a testis specific member of septin proteins, a fa...
متن کاملA single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest.
Genetic mechanisms have been implicated as a cause of some cases of male infertility. Recently, 10 novel genes involved in human spermatogenesis were identified by microarray analysis of human testicular tissue. One of these is spermatogenesis-associated 17 (SPATA17). To investigate whether defects in the SPATA17 gene are associated with azoospermia due to meiotic arrest, a mutational analysis ...
متن کاملSome single-nucleotide polymorphisms of the TSSK2 gene may be associated with human spermatogenesis impairment.
Tssk2, a member of the testis-specific serine/threonine kinase (TSSK) family, is expressed predominantly in the testis and is crucial for the formation and function of sperm cells in the mouse. Targeted deletion of Tssk1 and Tssk2 in male chimeric mice caused infertility because of haploinsufficiency of the genes. Therefore, it is reasonable to postulate that mutations in the human homolog TSSK...
متن کاملP-206: Mov10l1 Gene Polymorphisms Are Probably Associated to Male Infertility in Azoospermic Men with Complete Maturation Arrest
Background: Thousands of genes are involved in spermatogenesis. Alterations in any of these genes could lead to male infertility. Moloney leukemia virus 10-Like 1 (Mov10l1) gene is one of the genes that are expressed specifically in germ cells. Genetic disruption of this gene in mouse stops spermatogenesis during Meiosis I and causes azoospermia. Materials and Methods: In this study, the geneti...
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ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2011
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-011-9679-5